Structure of PDB 1hag Chain E Binding Site BS01

Receptor Information
>1hag Chain E (length=295) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPW
QVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIG
KHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDY
IHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVN
LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSP
FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
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PDB1hag The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		F34 K36 L65 T74 R75 Y76 K81 I82 M84
Binding residue
(residue number reindexed from 1)		F55 K57 L96 T105 R106 Y107 K113 I114 M116
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1hag, PDBe:1hag, PDBj:1hag
PDBsum1hag
PubMed7756983
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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