Structure of PDB 1fmo Chain E Binding Site BS01
Receptor Information
>1fmo Chain E (length=338) Species:
10090
(Mus musculus) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
ESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKH
KESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKD
NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL
IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS
KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS
SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA
PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
Ligand information
>1fmo Chain I (length=20) Species:
9986
(Oryctolagus cuniculus) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
TTYADFIASGRTGRRNAIHD
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1fmo
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
T51 S53 K83 E127 F129 R133 K168 P169 E170 L198 C199 G200 E203 E230 Y235 P236 F239 A240 D241 Y330
Binding residue
(residue number reindexed from 1)
T39 S41 K71 E115 F117 R121 K156 P157 E158 L186 C187 G188 E191 E218 Y223 P224 F227 A228 D229 Y318
Enzymatic activity
Catalytic site (original residue number in PDB)
N171 D184
Catalytic site (residue number reindexed from 1)
N159 D172
Enzyme Commision number
2.7.11.11
: cAMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004679
AMP-activated protein kinase activity
GO:0004691
cAMP-dependent protein kinase activity
GO:0004712
protein serine/threonine/tyrosine kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0019901
protein kinase binding
GO:0019904
protein domain specific binding
GO:0030145
manganese ion binding
GO:0031625
ubiquitin protein ligase binding
GO:0034237
protein kinase A regulatory subunit binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001707
mesoderm formation
GO:0001843
neural tube closure
GO:0006397
mRNA processing
GO:0006468
protein phosphorylation
GO:0006611
protein export from nucleus
GO:0007189
adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0016310
phosphorylation
GO:0018105
peptidyl-serine phosphorylation
GO:0032024
positive regulation of insulin secretion
GO:0034605
cellular response to heat
GO:0045542
positive regulation of cholesterol biosynthetic process
GO:0045667
regulation of osteoblast differentiation
GO:0045722
positive regulation of gluconeogenesis
GO:0045879
negative regulation of smoothened signaling pathway
GO:0046827
positive regulation of protein export from nucleus
GO:0048240
sperm capacitation
GO:0050804
modulation of chemical synaptic transmission
GO:0051726
regulation of cell cycle
GO:0061136
regulation of proteasomal protein catabolic process
GO:0070417
cellular response to cold
GO:0070613
regulation of protein processing
GO:0071333
cellular response to glucose stimulus
GO:0071374
cellular response to parathyroid hormone stimulus
GO:0071377
cellular response to glucagon stimulus
GO:0099170
postsynaptic modulation of chemical synaptic transmission
GO:0141156
cAMP/PKA signal transduction
GO:1904262
negative regulation of TORC1 signaling
GO:1904539
negative regulation of glycolytic process through fructose-6-phosphate
GO:1990044
protein localization to lipid droplet
GO:2000810
regulation of bicellular tight junction assembly
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005813
centrosome
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005930
axoneme
GO:0005952
cAMP-dependent protein kinase complex
GO:0016607
nuclear speck
GO:0031410
cytoplasmic vesicle
GO:0031514
motile cilium
GO:0031594
neuromuscular junction
GO:0036126
sperm flagellum
GO:0044853
plasma membrane raft
GO:0048471
perinuclear region of cytoplasm
GO:0097546
ciliary base
GO:0098794
postsynapse
GO:0098978
glutamatergic synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1fmo
,
PDBe:1fmo
,
PDBj:1fmo
PDBsum
1fmo
PubMed
9109651
UniProt
P05132
|KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha (Gene Name=Prkaca)
[
Back to BioLiP
]