Structure of PDB 1czi Chain E Binding Site BS01

Receptor Information
>1czi Chain E (length=323) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVASVPLTNYLDSQYFGKIYLGTPPQEFTVLFDTGSSDFWVPSIYCKSN
ACKNHQRFDPRKSSTFQNLGKPLSIHYGTGSMQGILGYDTVTVSNIVDIQ
QTVGLSTQEPGDVFTYAEFDGILGMAYPSLASEYSIPVFDNMMNRHLVAQ
DLFSVYMDRNGQESMLTLGAIDPSYYTGSLHWVPVTVQQYWQFTVDSVTI
SGVVVACEGGCQAILDTGTSKLVGPSSDILNIQQAIGATQNQYGEFDIDC
DNLSYMPTVVFEINGKMYPLTPSAYTSQDQGFCTSGFQSENHSQKWILGD
VFIREYYSVFDRANNLVGLAKAI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1czi A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Q13 D32 Y75 G76 T77 V111 F112 Y114 A115 D215 G217 S219 K220 Q287
Binding residue
(residue number reindexed from 1)		Q15 D34 Y77 G78 T79 V113 F114 Y116 A117 D216 G218 S220 K221 Q288
Enzymatic activity
Enzyme Commision number 3.4.23.4: chymosin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1czi, PDBe:1czi, PDBj:1czi
PDBsum1czi
PubMed9862200
UniProtP00794|CHYM_BOVIN Chymosin (Gene Name=CYM)

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