Structure of PDB 1ca9 Chain E Binding Site BS01

Receptor Information
>1ca9 Chain E (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKR
QEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMK
GPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNI
ASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
Ligand information
Receptor-Ligand Complex Structure
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PDB1ca9 Structural basis for self-association and receptor recognition of human TRAF2.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E367 R372 I373
Binding residue
(residue number reindexed from 1)		E52 R57 I58
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1ca9, PDBe:1ca9, PDBj:1ca9
PDBsum1ca9
PubMed10206649
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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