Structure of PDB 1br4 Chain E Binding Site BS01

Receptor Information
>1br4 Chain E (length=781) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AQKPLSDDEKFLFVDKNFVNNPLAQADWSAKKLVWVPSEKHGFEAASIKE
EKGDEVTVELQENGKKVTLSKDDIQKMNPPKFSKVEDMAELTCLNEASVL
HNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPP
HIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSP
SFSYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIV
GANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNY
TFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEEEQTSILRVVSSVLQLG
NIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDV
VQKAQTKEQADFAIEALAKAKFERLFRWILTRVNKALDASFLGILDIAGF
EIFEINSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGL
DLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKF
QKSKQLKDKTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDK
FVADLWKDVDRIVGLFRTVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHE
KRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAAN
AIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDL
KITDVIIAFQAQCRGYLARKAFAKRQQQLGS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1br4 Chain E Residue 997 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1br4 Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
Resolution3.62 Å
Binding residue
(original residue number in PDB)		T184 S246
Binding residue
(residue number reindexed from 1)		T183 S233
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S179 G180 T184 N242 S245 S246 G468 E470
Catalytic site (residue number reindexed from 1) S178 G179 T183 N229 S232 S233 G449 E451
Enzyme Commision number 3.6.1.32: Transferred entry: 5.6.1.8.
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1br4, PDBe:1br4, PDBj:1br4
PDBsum1br4
PubMed9741621
UniProtP10587|MYH11_CHICK Myosin-11 (Gene Name=MYH11)

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