Structure of PDB 1bll Chain E Binding Site BS01

Receptor Information
>1bll Chain E (length=481) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGLVLGIYSKEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRT
FYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQIQDL
EIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSEDQEA
WQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIR
PKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGIT
FDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLC
ENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKV
IINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLF
EHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGV
MTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQ
Ligand information
Receptor-Ligand Complex Structure
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PDB1bll X-ray crystallographic determination of the structure of bovine lens leucine aminopeptidase complexed with amastatin: formulation of a catalytic mechanism featuring a gem-diolate transition state.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D255 K262 M270 D273 D332 T359 L360 T361 G362 A363 I366 R425
Binding residue
(residue number reindexed from 1)		D252 K259 M267 D270 D329 T356 L357 T358 G359 A360 I363 R422
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.5: prolyl aminopeptidase.
3.4.13.23: cysteinylglycine-S-conjugate dipeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0008233 peptidase activity
GO:0016805 dipeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
GO:0097718 disordered domain specific binding
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1bll, PDBe:1bll, PDBj:1bll
PDBsum1bll
PubMed8357796
UniProtP00727|AMPL_BOVIN Cytosol aminopeptidase (Gene Name=LAP3)

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