Structure of PDB 7ucj Chain Dd Binding Site BS01

Receptor Information

>7ucj Chain Dd (length=55) Species: 9986 (Oryctolagus cuniculus)

GHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIG
FIKLD

Ligand information

>7ucj Chain 9 (length=1698)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
cccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggu
agucgccgugccuaccauggugaccacgggugacggggaaucaggguucg
auuccggagagggagccugagaaacggcuaccacauccaaggaaggcagc
aggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaaua
acaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaa
auccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcg
guaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcu
cguaguuggaucuugggagcggccguccccugcucggcgccggcccgaag
cguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccg
cagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucgg
aacugaggccaugauuaagagggacggccgggggcauucguauugcgccg
cuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcau
uugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaaga
cgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaug
cggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagu
cuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauu
gacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaac
acgggaaaccucacccggcccggacacggacaggauugacagauugauag
cucuuucucgauuccgugggugguggugcauggccguucuuaguuggugg
agcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaa
cuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccuuagauguc
cggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuac
gccggcaggcgcggguaacccguugaaccccauucgugauggggaucggg
gauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucau
aagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcua
cuaccgauuggaugguuuagugaggcccucggaucggccccgccggggug
cccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<...........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<
<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>.
...>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>
>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>....
.<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<......
.....>..>>.........<<<<<((......<<<<.....<<..))>>.
......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<
<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>
>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>...
...>.>>>..>>>........<.<<.<<<<<<<...............>>
>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<
...<<<......>>>......>>>>>>>>..>>.......<<....>>..
.>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<
<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.
<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>
.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<
<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<.<....<<<<<........<<.<<<.......
.>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<
<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<
..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<..
...>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>
>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<
<<<....>>>>.>>>....>.........>>>.>>......<.....<<<
<<..........>>>>>.....>.....>>>>>.....<<<<<<<<....
...>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<
<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..
>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ucj Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): G2 H3 L6 Y7 S9 H10 R12 K13 F14 Q16 G17 R19 R22 C24 H28 I31 R32 Y34 R40 Q41 R44 K54 D56
• Binding residue (residue number reindexed from 1): G1 H2 L5 Y6 S8 H9 R11 K12 F13 Q15 G16 R18 R21 C23 H27 I30 R31 Y33 R39 Q40 R43 K53 D55

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005791 rough endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ucj, PDBe:7ucj, PDBj:7ucj
• PDBsum: 7ucj
• PubMed: 35679869
• UniProt: G1U7M4|RS29_RABIT Small ribosomal subunit protein uS14 (Gene Name=RPS29)