Structure of PDB 6zqb Chain Db Binding Site BS01

Receptor Information

>6zqb Chain Db (length=81) Species: 559292 (Saccharomyces cerevisiae S288C)

VLVQDLLHPTAASEARKHKLKTLVQGPRSYFLDVKCPGCLNITTVFSHAQ
TAVTCESCSTILCTPTGGKAKLSEGTSFRRK

Ligand information

>6zqb Chain D3 (length=1198)

aagauaguuaucugguugauccugccagucauaugcuugucucagccaug
cagucuaaguauaagcaauuuauacagugaaacugcgaaugcucauuaaa
ucaguuaucguuuauuugauagucaugguauaacugugguaauucuagag
cuaaaaucucgacccuuuggaagagauguauuuauuagaucaaugucuuc
ggacucuuugaugaauaacuuuucgaaucgcauggccuugugcuggcgau
gguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggcc
uaccaugguuucaacggguaacggggaauaaggguucgauuccggagagg
gagccugagaaacggcuaccacauccaaggaagggcaggcuuacccaauc
cuaauucagggagguagugacaauaaauaacgauacagggcccauucggg
ucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauug
gagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgu
auauugcucguaguugaacuuugggcccgguuggccggucggauuuccaa
cggggccuuuauuaauagggacggucgggggcaucaguauucaauuguca
gaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuug
ccaaggacguuuucauuaaucaagaacgaaaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggu
cgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggaaacucaccagguccagacacaauauuugugggugguggug
caugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagu
cuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaa
uuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuu
uguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccuc
aggaucugcuuagagaagggggcaacuccucucagagcggagauuuggac
aaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga

..............................<<<<<<...<....<<<.<<
<.<<....<.....<............>....>.>>.....<<<......
.<<<..<<..<<....<<<..............<<.<<<.....>>>.>>
.....<<<<<..<......>..>>>>>....<<<<...<<<<<.<<<...
.>>>...>>>>>..>>>>.........<<<<..<<<.....>>>.>>>>.
...>>>...>>>>..>>>.<<<....<<.....<<<<<<<<.......>>
>>>>>>.>>......>>>.....<<...............>>..>>>.<<
.<<<..........>>>.>>.<.<<....>>.>.>>>>>>..<<<....<
<<.....>>>..>>>.........>.....<<<<<<<.<<<<<....>>>
>>.>>>.>>>>......<<..<...........>..>>.........<<<
<<<.......<<<....>>>..................>>>>>>..>>>>
>>...<.<<...<<<.<<.....<<<<<.<<<<<............>>>>
>.>>>>>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...
<<<......>>>......>.>>>>>>..>>.......<<....>>...>>
>>...>>>>>.>>>...>>>...>>.>............<<...<<<..<
<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>...........
.......<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..
<<<.<<<<........<<<<..<....<<<<<...>>>>>......<<<<
.......>>>>...>..>>>>>>>>.>>>.....<<<<<<<.........
...<<<..<<<<....>>>>..>>>.....>>>>>>>............>
>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>
............>>>>>..<<<<.<<....<<<<<<<<.<<.....<<..
....<<<<<<<.<<<<.<.<......>.>>>>>.>>>>>>>.....>>..
...>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqb 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): R17 H19 K20 L21 S30 Q51 G68 G69 K70
• Binding residue (residue number reindexed from 1): R16 H18 K19 L20 S29 Q50 G67 G68 K69

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0044391 ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zqb, PDBe:6zqb, PDBj:6zqb
• PDBsum: 6zqb
• PubMed: 32943521
• UniProt: P35997|RS27A_YEAST Small ribosomal subunit protein eS27A (Gene Name=RPS27A)