Structure of PDB 6zqc Chain DW Binding Site BS01

Receptor Information

>6zqc Chain DW (length=129) Species: 559292 (Saccharomyces cerevisiae S288C)

TRSSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLQVMQKHGYIGEFE
YIDDHRSGKIVVQLNGRLNKCGVISPRFNVKIGDIEKWTANLLPARQFGY
VILTTSAGIMDHEEARRKHVSGKILGFVY

Ligand information

>6zqc Chain D3 (length=1327)

aagauaguuaucugguugauccugccagucauaugcuugucucaaagauu
aagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauagcaugguauaacuguggua
auucuagagcuaauacaugcuaucucgacccuuuggaagagauuauuuau
uagauucuucggacucuugaugauucauaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaa
auaacgauacagggcccauucgggucuuguaauuggaaugaguacaaugu
aaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccg
cgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggc
ccgguuggccggucggauuuccaacggggccuuuuuacuuugaaaaaauu
agaguguucaaagcaggcguauugcucgauauauuagcauggaauaauag
gacguuugguucuauuuuguugguuucuaggaccaucguaauuaauaggg
acggucgggggcaucaguauucaauugucagaggugaaauucuuggauuu
auugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaau
caagaacgaaacuaugccgacuagggaucgggugguguuuuuuuaaugac
ccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaagga
auugacggaagggcaccaccaggaguggagccugcggaaacucaccaggu
ccagacacaauauuugugggugguggugcaugugaugcccuuguucuggc
gcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuu
gguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucauc
agcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuag
uaccgauugaauggcuuagugaggccucaggaucugcuuagagaaggggg
caacuccaucucagagcggaaauuuggacaaacuuggucauuuagaggaa
cuaaguuuccguaggugaaccugcgga

...........................<<.<<<<<<...<.<........
..<<<.<<<..<<....<<....<<..........>>...>>.>>.....
.<<..<.....<<<..<<..<<....<<<.......<<....<<.<<<..
...>>>.>>.....>>.....<<<<<..<<....>>..>>>>>...<<<<
<<...<<....>>....<<......>>>>>>>>.........<<<<.<<<
<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<......<
<<<<<<.......>>>>>>>..>>......>>>...<<<<<<<<....>>
>>...>>>>>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>..
.>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.
....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<....
.......>..>>.........<<<<<<.......<<<....>>>......
............>>>>>>..>>>>>>>>.<.<<...<<<.<<....<<<<
<<.<<<<<............>>>>>.>>>>>>..<<<<<.<<......<.
...<<.......>>..<<.....>>.....>......>>.>>..>>>...
.<<<...<<<<<<...............>>>>>>..>>>..>>....<<<
<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.
>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>
...>>.>..........<<...<<<..<<<<<<<<.<<<........>>>
>>>>>>>>..>>>..>>..................<<.........>>..
...<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<<<<.
<....<<<<<...>>>>>......<<<.<<..>>..>>>...>.>>>>>>
>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..
>>>.....>>>>>>>............>>>>>>....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>............>>>>>..<<<
<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<...<<.<.<..
....>.>.>>...>>>>>>>..>..>>.>..>>>.>>>>>>>>...>>.>
>>>....<<<<<<<<....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqc 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): T2 V6 K22 R28 K32 H56 R57 N80 K82 T105 T106 S107 A108 H120 K124
• Binding residue (residue number reindexed from 1): T1 V5 K21 R27 K31 H55 R56 N79 K81 T104 T105 S106 A107 H119 K123

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zqc, PDBe:6zqc, PDBj:6zqc
• PDBsum: 6zqc
• PubMed: 32943521
• UniProt: P0C0W1|RS22A_YEAST Small ribosomal subunit protein uS8A (Gene Name=RPS22A)