Structure of PDB 7zux Chain DS Binding Site BS01

Receptor Information
>7zux Chain DS (length=145) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKAD
VDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTL
ANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA
Ligand information
>7zux Chain 2 (length=1769) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuccuucuggcuaaccuugagcuugg
cgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgua
uugcucgaauauauuagcauggaauaauagaauaggacguuugguucuau
uuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggc
aucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaa
cuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaag
uuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacua
ugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuu
acgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcug
aaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggc
uuaauuugacucaacacggggaaacucaccagguccagacacaauaagga
uugacagauugagagcucuuucuugauuuugugggugguggugcauggcc
guucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgag
accuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucu
uagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggu
cugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggag
ccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacucc
gucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuc
cuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuugu
acacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucagg
aucugcuuagagaagggggcaacuccaucucagagcggagaauuuggaca
aacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggug
aaccugcggaaggaucauu
...<<<<<.{.(((.>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<<....<<
.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>
>>><.<.<<<<<<......(((..((.<.<....>.>.....<......>
.>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<.<<<....>>>.>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<.....<<<<<.<<<
<..............>>>>.>>>>>....<<<<<................
....>>>>>....<<<<<.<<.......<<...<.......>..<<<<..
.>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.
....))..))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<
<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>..
.....<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<
<<<<<<...<...<<<<.........>>>>...>>>>>>>>.........
.<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>.
..<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>.
...>>>...))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<
......<<........>>..........<<<<<.<....<<<<<......
..<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<
<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>...
.<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>
>>>.>>...<<<<<<<.....>>>>>>>......>>>>>....>>>.>>>
.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<
......<<.....<<..<<<<....>>>>..>>....>>.......>>>>
>>>...........<<<<<<..........>>>>>>..........>>>>
>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<..
.<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zux Structural basis for clearing of ribosome collisions by the RQT complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K27 Y30 K36 G37 V38 G39 R40 R41 Y42 W84 F85 N87 R88 L109 D112 R115 H122 R123 R126 H127 L131 R132 V133 R134 Q136 H137 T138 K139 T140 R143 R144 R145
Binding residue
(residue number reindexed from 1)		K26 Y29 K35 G36 V37 G38 R39 R40 Y41 W83 F84 N86 R87 L108 D111 R114 H121 R122 R125 H126 L130 R131 V132 R133 Q135 H136 T137 K138 T139 R142 R143 R144
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zux, PDBe:7zux, PDBj:7zux
PDBsum7zux
PubMed36801861
UniProtP0CX55|RS18A_YEAST Small ribosomal subunit protein uS13A (Gene Name=RPS18A)

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