Structure of PDB 7zux Chain DR Binding Site BS01

Receptor Information

>7zux Chain DR (length=121) Species: 4932 (Saccharomyces cerevisiae)

GRVRTKTVKRASKALIERYYPKLTLDFQTNKRLCDEIATIQSKRLRNKIA
GYTTHLMKRIQKGPVRGISFKLQEEERERKDQYVPEVSALDLSRLNVDNQ
TSDLVKSLGLKLPLSVINVSA

Ligand information

>7zux Chain 2 (length=1769)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuccuucuggcuaaccuugagcuugg
cgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgua
uugcucgaauauauuagcauggaauaauagaauaggacguuugguucuau
uuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggc
aucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaa
cuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaag
uuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacua
ugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuu
acgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcug
aaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggc
uuaauuugacucaacacggggaaacucaccagguccagacacaauaagga
uugacagauugagagcucuuucuugauuuugugggugguggugcauggcc
guucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgag
accuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucu
uagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggu
cugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggag
ccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacucc
gucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuc
cuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuugu
acacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucagg
aucugcuuagagaagggggcaacuccaucucagagcggagaauuuggaca
aacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggug
aaccugcggaaggaucauu

...<<<<<.{.(((.>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<<....<<
.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>
>>><.<.<<<<<<......(((..((.<.<....>.>.....<......>
.>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<.<<<....>>>.>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<.....<<<<<.<<<
<..............>>>>.>>>>>....<<<<<................
....>>>>>....<<<<<.<<.......<<...<.......>..<<<<..
.>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.
....))..))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<
<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>..
.....<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<
<<<<<<...<...<<<<.........>>>>...>>>>>>>>.........
.<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>.
..<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>.
...>>>...))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<
......<<........>>..........<<<<<.<....<<<<<......
..<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<
<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>...
.<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>
>>>.>>...<<<<<<<.....>>>>>>>......>>>>>....>>>.>>>
.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<
......<<.....<<..<<<<....>>>>..>>....>>.......>>>>
>>>...........<<<<<<..........>>>>>>..........>>>>
>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<..
.<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zux Structural basis for clearing of ribosome collisions by the RQT complex.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): G2 R3 V4 R5 T6 K7 K10 R11 F28 K32 S43 R45 N48 K49 H56 K59 R60 R67
• Binding residue (residue number reindexed from 1): G1 R2 V3 R4 T5 K6 K9 R10 F27 K31 S42 R44 N47 K48 H55 K58 R59 R66

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7zux, PDBe:7zux, PDBj:7zux
• PDBsum: 7zux
• PubMed: 36801861
• UniProt: P02407|RS17A_YEAST Small ribosomal subunit protein eS17A (Gene Name=RPS17A)