Structure of PDB 6hiw Chain DL Binding Site BS01

Receptor Information
>6hiw Chain DL (length=283) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKRRVIVPIHPTPNFPAHFIKSAFTTDPLKEKQKARFSSGGEAMREVQDI
PKNLEGERSRRDLASRGDTEFQALVEFIEGASYDQLISGRRFKKVYDVLS
ENDDMFIWLCHTAMSVLNPGDMRSRLIYNHLRILAESVASGEMTQRTAFR
FFESAVRSPAYREIAKRQLEGGAATRLAGISAAADVMRRMGLTRRPMSSY
FELYQRIVERSEAMTPWGFPPLFQFEERLSLEPRLKFFSRASGHVMTPHT
TLHGRRIFWIPPTWNRAGRFLGPHVTLYPGMTP
Ligand information
>6hiw Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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ucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuagg
aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaaguguug
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....................<<<.......<<<<..............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.<<<<<............................................
..................................................
.....................>>>>>..................>>....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.37 Å
Binding residue
(original residue number in PDB)		K16 R18 V21 K46 H267 V268 M269 H272 H276 R278 R289 L294 L300 Y301
Binding residue
(residue number reindexed from 1)		K2 R4 V7 K32 H244 V245 M246 H249 H253 R255 R266 L271 L277 Y278
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

View graph for
Cellular Component
External links
PDB RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
PDBsum6hiw
PubMed30213880
UniProtQ38BS2

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