Structure of PDB 6zqe Chain DI Binding Site BS01

Receptor Information

>6zqe Chain DI (length=177) Species: 559292 (Saccharomyces cerevisiae S288C)

GISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGG
NKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAI
VQIDATPFRQWFEAHYGQTLGKRAASAKIESSVESQFSAGRLYACISSRP
GQSGRCDGYILEGEELAFYLRRLTAKK

Ligand information

>6zqe Chain D3 (length=1447)

ucugguugauccugccaguagucauaugcuugucucaaagauuaagccau
gcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauu
aaaucaguuaucguuuauuugauagucaugguauaacugugguaauucua
gagcuaauacaugcuaucucgacccuuuggaagagauguauuuauuagau
aaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaa
ucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaa
cuuucgaugguaggauaguggccuaccaugguuucaacggguaacgggga
auaaggguucgauuccggagagggagccugagaaacggcuaccacaucca
aggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagu
gacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugag
uacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugcc
agcagccgcgguaauuccagcuccaauagcguauauuguuguugcaguua
aaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaac
ggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaacc
aggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcuc
gaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguu
gguuucuaggaccaucguaaugauuaauagggacggucgggggcaucagu
auucaauugucagaggugaaauucuuggauuuauugaagacuaacuacug
cgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggg
gaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccga
cuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaga
aaucaaagucuuuggguucugggggaguauggucgcaaggcuaaaaaagg
aauugacggaagggcaccaccaggaguggagccugcggcgcgcuacacug
acggagccagcgagaccuuggccgagaggucuugggaaacuccgucgugc
uggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaa
gcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacacc
gcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcu
uagagaagggggcaacuccaucucagagcggagauuuggacaaacuuggu
cauuuaggaacuaauuccguaggugaaccugcggaaggaucauuaaa

.<<<<<.......>>>>>.....((((((................[[[.[
[[..<<....<<....<<..........>>...>>.>>......{{....
....[[[..{{..{{....[[[........<<....<<.<<<.....>>>
.>>.....>>.....<<<<<..<<....>>..>>>>>[...((((((...
...<<<<<<<.<<<....>>>....<<......>>)))))).....]...
<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<
<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<
<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<..
..>>.>...]]]]]].........<<<....<<<.....>>>..>>>...
............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<
<..<...........>..>>.........<<<<<<.......<<<....>
>>..................>>>>>>..))))))..........[[[<<.
......{{...[[[.[[....<<<<<<.<<<<<............>>>>>
.>>>>>>....<<<<<<........<<<<.......>>>>........>>
>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>.
...>>......>>.>>..>>>.........[[...[.(((((......>>
>>>>>..))))).]..]].....]]....<<<<<<.<<...<<<<..<<.
.<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<
<....>>...>>>>..>>.>>>.>>>...]]]...}}......<<<<<<<
...<...<<<...........>>>...>>>>>>>>..........<<<.<
<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..
>>>>...>>.....>>>.]]].............................
....<<<<<<<<<<<<..<<.<<<<<...<<<.<<<.>>>.>>>.....<
<<<<<<.........<<..<<<<....>>>>..>>....>>>>>>>....
.......<<<<<<..........>>>>>>...........>>>>>....<
<<<<<<<.......>>>>>>>>......>>...>>>>>>>..........
..>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<
<.<<<<.<<<......>>>.>>>>.>>>>>>>..>..>>.>..>>>.>>>
>>>>>.>>.>>>>.<<<<<<<<<....>>>>>>>>>...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqe 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 7.1 Å
• Binding residue (original residue number in PDB): G2 R5 D6 K10 R11 T14 G15 A16 K24 R25 K26 F27 R31 Q32 P33 R42 I43 T48 G50 S66 A68 S73 S86 T97 K98 A99 G174 D180
• Binding residue (residue number reindexed from 1): G1 R4 D5 K9 R10 T13 G14 A15 K23 R24 K25 F26 R30 Q31 P32 R41 I42 T47 G49 S65 A67 S72 S85 T96 K97 A98 G151 D157

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030686 90S preribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zqe, PDBe:6zqe, PDBj:6zqe
• PDBsum: 6zqe
• PubMed: 32943521
• UniProt: P0CX39|RS8A_YEAST Small ribosomal subunit protein eS8A (Gene Name=RPS8A)