Structure of PDB 6zqf Chain DH Binding Site BS01

Receptor Information

>6zqf Chain DH (length=184) Species: 559292 (Saccharomyces cerevisiae S288C)

PQAKILSQAPTELELQVAQAFVELENSSPELKAELRPLQFKSIREIDVAG
GKKALAIFVPVPSLAGFHKVQTKLTRELEKKFQDRHVIFLAERRILPKPS
RTSRQVQKRPRSRTLTAVHDKILEDLVFPTEIVGKRVRYLVGGNKIQKVL
LDSKDVQQIDYKLESFQAVYNKLTGKQIVFEIPS

Ligand information

>6zqf Chain D3 (length=1392)

uaucugguugauccugccaguucauaugcuugucucaaagauuaagccau
gcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauu
aaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugu
gguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagaga
uguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucau
aauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaau
uucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuca
acggguaacggggaauaaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaa
uucagggagguagugacaauaaauaacgauacagggcccauucgggucuu
guaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauau
uauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgg
ucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuugugg
cucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagc
aggcguauugcucgaauauauuagcauggaauaauagaauaggacguuug
guucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggu
cgggggcaucaguauucaauugucagaggugaaauucuuggauuuauuga
agacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaaga
acgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacca
uaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucg
gcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgc
aaggcuaaauuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgag
aggucuugguaaucuugugaaacuccgucgugcuggggauagagcauugu
aauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuu
gcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccg
gaacuaauuccguaggugaaccugcggaaggaucauuaaaga

...<<<<<.......>>>>>...<<<<<<...<.<..........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<..<<..<<....<<<..................<.....<<.<
<.......>>.>>......>.........<<<<<..<<....>>..>>>>
><...<<<<<<.........(((..<<<....>>>..............>
>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>
..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<..
...>>>..>>>.......>.>.....<<<<<..<.<..........>.>.
.>>.>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>..................>>>>>>..>>>>>>..
.......<<<.[.....<.<<...<<<.<<....<<<<<<.<<<<<....
<..>....>>>>>.>>>>>>....<<<<<<....................
...........>>>>>>...<<<<<.<<.......<<...<.......>.
.<<<.....>>>....>>......>>.>>..>>>.........<<...<<
<<<<<<......)))....>>>>>>>>..>>.....>>....<<<<<<.<
<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>
.>.>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>
.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..
........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>
>..>>>...<<..].>>...>>.....>>>.>>>................
....................<<<<<<<<<<<<..<<..<<<<<..<<<.<
<<.....>>>.>>>.....<<<<<<<......<<.....<<..<<<<...
.>>>>..>>....>>.......>>>>>>>...........<<<<<<....
......>>>>>>..........>>>>>.....<<<<<<<.........>>
>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<>
>.>>>>.<<<<<<<<<....>>>>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqf 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 4.9 Å
• Binding residue (original residue number in PDB): R96 R97 Q108 P113 S115 T117 L118 T177 G178
• Binding residue (residue number reindexed from 1): R93 R94 Q105 P110 S112 T114 L115 T174 G175

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zqf, PDBe:6zqf, PDBj:6zqf
• PDBsum: 6zqf
• PubMed: 32943521
• UniProt: P26786|RS7A_YEAST Small ribosomal subunit protein eS7A (Gene Name=RPS7A)