Structure of PDB 8c3a Chain DG Binding Site BS01 |
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| >8c3a Chain CM (length=1765)
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uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgu
gguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaaggga
uguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucau
aauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaau
uucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuca
acggguaacggggaauaaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccga
cacggggagguagugacaauaaauaacgauacagggcccuuuugggucuu
guaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauau
uaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcugg
ccgguccauaugcguacuggacccagccgagccuuuccuucuggguagcc
auuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaag
caggccuuugcucgaauauauuagcauggaauaauagaauaggacguuau
gguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacgg
ucggggguaucaguauucaguugucagaggugaaauucuuggauuuacug
aagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaag
aacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacc
auaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaauc
ggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucg
caaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaacucaccagguccagacac
aauaaggauugacagauugagagcucuuucuugauuuugugggugguggu
gcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaa
cgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguaua
gucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggca
auaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuaca
cugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuu
gugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaa
cgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagug
aggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaac
uuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaac
cugcggaaggaucau |
...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<...............<<.....<..<
<.......>>..>......>>........<<<<<..<<....>>..>>>>
><...<<<<<<.......{.((((.<<<....>>>..............>
>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>
..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<.
..>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>
>>>.>>>......<<..<...........>..>>.........<<<<<((
......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>
>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<..
.......<..>.............>>>>>>>>>>.....<<<<.......
.............>>>>....<<<<<.<<.......<<...<.......>
..<<<....>>>....>>......>>.>>..>>>.........<<<..<<
<<<<<<<.....)))).}..>>>>>>>>>>>>.....>>....<<<<<<.
<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>
>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>
>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.
.........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>
>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<.
...>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<
<.<<<<<<......<<........>>..........<<<<<.<....<<<
<<........<<.<<<........>>>.>>......>>>>>...<<.<<<
..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>
>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>..
..>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>..
...>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>...
..<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<.
.<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>
>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>
>>>>>>>>....... |
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| PDB | 8c3a New crystal system to promote screening for new eukaryotic inhibitors |
| Resolution | 3.0 Å |
Binding residue
(original residue number in PDB) | P2 G3 V4 R7 Q12 I15 V37 K38 T39 A41 N43 D44 L45 P46 P47 Q48 R57 S60 R63 H64 R68 K69 G72 V73 G74 A75 G81 K84 N85 R86 G87 F88 R89 P90 H91 H93 S97 G98 S99 R102 Q106 G121 R122 Q129 R130 D133 |
Binding residue
(residue number reindexed from 1) | P1 G2 V3 R6 Q11 I14 V36 K37 T38 A40 N42 D43 L44 P45 P46 Q47 R56 S59 R62 H63 R67 K68 G71 V72 G73 A74 G80 K83 N84 R85 G86 F87 R88 P89 H90 H92 S96 G97 S98 R101 Q105 G120 R121 Q128 R129 D132 |
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| Enzyme Commision number |
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