Structure of PDB 7zx0 Chain DDD Binding Site BS01

Receptor Information
>7zx0 Chain DDD (length=633) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIDDGFPIKGCDDTLV
VGLAVCWGGRDAYYFSLQKVPPSLDPSLTLKDRMWYLQSCLRKESDKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLN
SLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLD
AIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHP
LPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRI
TFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELR
ILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICY
GIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRD
GFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVN
IQKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQI
VKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		K2209 A2238 T2243 F2244 T2245 N2248 G2388 Y2391 M2393 G2394 S2397 R2448 Y2459 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		K317 A346 T351 F352 T353 N356 G451 Y454 M456 G457 S460 R511 Y522 H526 R529 N533 Q537
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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