Structure of PDB 7q5w Chain DDD Binding Site BS01

Receptor Information
>7q5w Chain DDD (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA
HGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP
FNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEK
LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALC
LLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLT
VPCQKIG
Ligand information
>7q5w Chain GGG (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PYQELQGQRSDVYSDLNT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7q5w The tandem SH2 domains of SYK
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R22 R42 H63 Y64 T65 I76 A77 G78 G98 R175 R195 R197 H215 Y216 R217 I228 E230 G231 K232 K247 D249 G250 L251
Binding residue
(residue number reindexed from 1)		R16 R36 H57 Y58 T59 I70 A71 G72 G92 R169 R189 R191 H209 Y210 R211 I222 E224 G225 K226 K241 D243 G244 L245
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5w, PDBe:7q5w, PDBj:7q5w
PDBsum7q5w
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

[Back to BioLiP]