Structure of PDB 7q5u Chain DDD Binding Site BS01

Receptor Information
>7q5u Chain DDD (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS
VAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLK
KPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQL
EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYA
LCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRV
LTVPCQKI
Ligand information
>7q5u Chain HHH (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QLYQPLKDREDDQYSHLQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q5u The tandem SH2 domains of SYK
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R22 R42 H63 Y64 T65 I76 G98 L99 R175 R195 R197 H215 Y216 R217 I228 K232 K247 D249 G250 L251
Binding residue
(residue number reindexed from 1)		R18 R38 H59 Y60 T61 I72 G94 L95 R171 R191 R193 H211 Y212 R213 I224 K228 K243 D245 G246 L247
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5u, PDBe:7q5u, PDBj:7q5u
PDBsum7q5u
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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