Structure of PDB 6hiw Chain DD Binding Site BS01

Receptor Information
>6hiw Chain DD (length=791) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRSGKARAFVFRDPSLRMMRAGSGYQQLRRMGMPMQVGMGWRKVDSFHAN
TQYQHAWPLLSHDDLGNSDQSNNTKNIMYSMYMPKRNKGTAPWFRGADTY
SVKYCEQGRYEYQRYLMINRFPSEYKKHFLSFLSNIRMSSGSATIPQEAL
HWLLRMIVDNFNPQHVHYIAAMKTLQSAGELDMARDVWKIMERQQTWPCT
ATICAYLDVCVEAGEKTWAMEAWNRYCTELKFLEPGEVDPKPISRVPFSL
TREELLYLPKWKKHFDHDPNLDVMDLNRFNRTREVYLRMAQVMLAGGERN
AFQHFFTKLEEAMLNKPTPVPEPPNPHLVRRPRWAPYEHCKSVHHSPWRL
QNNGRALALGPPVTIEDEMQSRFFSNDQFLVHSVKEVLRIVLQEHKRAHP
TECTRCKTEAFFYKTKDADETLKFCDDLIERLFASLGVRLSNLNTSSLLS
TILEVFRVVGKESGAALLQRANEFLERKASLGDAEGSRENLTASNYLQVL
SGFADESAFVYNTKKDGTCQYKTGFDPRTTMRHLADVVQEIAGNPHVTWA
ADMHLQVVETMVGCGTMKANDYFVRNVLRQFSWDSRFLEALYVEYRRQDD
VDMWAELTKRALVWTARYNAPASERLRRLIEDDYDTIRVQTRTFRELAVF
QFRDVEERRHSRDVVNELPNPWYDYVAHALPFPDRDAGYPDEYGDLGQWR
APGGPGSPVRGPRGYTAEWRDLRNPMRPPEFPTPWERKYRQYARGQHPSY
DMVYAGPMPEIFPMRRDFRKPTRWDFHDIEKQGKYRTSGPY
Ligand information
>6hiw Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaaguguug
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uaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuu
auauuaaauauguauguguagauaaaauaagaaauuaaaaagguauuguu
gcccaccaauuuuuauaauaaaaauaacgugcaguaauuaauauauuuau
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....................<<<.......<<<<..............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.<<<<<............................................
..................................................
.....................>>>>>..................>>....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
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PDB6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.37 Å
Binding residue
(original residue number in PDB)
H10 R11 S12 K14 A15 R16 A17 R21 M27 R29 Y34 M44 V46 G47 G49 W50 K52 F56 H57 G75 R95 K97 D107 T108 Y109 S110 K136 S140 S143 S151 A152 R339 R342 Q707 W708 A710 Y763 D772 M773 K805
Binding residue
(residue number reindexed from 1)
H1 R2 S3 K5 A6 R7 A8 R12 M18 R20 Y25 M35 V37 G38 G40 W41 K43 F47 H48 G66 R86 K88 D98 T99 Y100 S101 K127 S131 S134 S142 A143 R330 R333 Q698 W699 A701 Y742 D751 M752 K784
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000963 mitochondrial RNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0031019 mitochondrial mRNA editing complex

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
PDBsum6hiw
PubMed30213880
UniProtQ385L8

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