Structure of PDB 6hiw Chain DC Binding Site BS01

Receptor Information

>6hiw Chain DC (length=1095) Species: 5702 (Trypanosoma brucei brucei)

YTPIWKSDPAVDNVAPLRDEDERRALWAEVGPISDVGSAVTAWIRFGNDP
VLHTAVPTMLGGKFRNQQREKESLLPNSSSPFAYVEDYMGTNLVFGSPVH
AKESAAVWATYFERRYASRLRLSRRTVANYVGLINSPEVFDDESDRPETR
WSQDTFFRECAYLSEKFLKEKVSNMQQFEAALKRASPEAYLAFFDAFQQQ
TQTQIPLPSPSVWHYEGERRKQWAEKFISISHKAQAFFKDVLSEDVKKYQ
EVPGKLLQKVKPVLADVGKILVKRHERWLKGRVWTSLTEEEREAYCMKEV
KRQQMQVEDGEFDPMMEDDVDDTELEEWQREHDAIMKLMNSPIDGLHFTT
LELWLHTMRCEELETEHIYTSARVRAIQVAARKKLYDTTSYEEVIQAVVE
SIARGTLDLGAGVLRPHFNEVWCQLNYAKFGSSTITQHTTTSRRQLLFFH
AGSLKDIAATATLYYATKPLSNSLDYASPYKYRRSLITLCSNYGVETAYT
TQRPLLRSAANLARAEDLIHAVVTAAAQPFGERRRAATRDLHMEFQRLAV
PVERVIVANPVSALLESGADPDEKPVEGEKVNMWPLGAKRVVLYKWSAPN
VEKLKAMESDASLTAKRLREIQELKRRGFLEVSLWRRVTAQERKQRNEIV
EAKKKQVEEVVRTVPSLAHLHQYATSLYSRIEERVAEWEFAVLLDDRVLL
NKEESVELYLPYRDANGELLAQGEYRALVRAFDLEANPNLHPAYCSVGYS
ESFQVFDALPQLIAQFFRVTHIPAADFTPFCAFLRDAGLDVPLRCEFEAG
QAVTTDGDVYMDYFLQLLRGEAFHQSHAQAGLTEAQRAIEPLCRAHWVVH
HPGADESEWATARRSVLDHAMQHEREWWFPNEMLDVKDVVTGSTNGLTPQ
MYPAAVRYGVELCTVLTAEGKFVDERGSGLSARCVVNGTGAAESVVFDTA
NCNGTNTTSVEDALRVAHGALRSAQDRHNTLAAFRLGPLSKQSQVLLFCG
VNAYEFGGKYARTYAYAFEKAKKELEATAASGFMAPSLSHEDTERLSDQP
TTSPSVDRFASTTHPEQRKAQFVPRVGPGSTPLEDPAADQKSEWS

Ligand information

>6hiw Chain UO (length=5) Species: 5702 (Trypanosoma brucei brucei)

PPPPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
• Resolution: 3.37 Å
• Binding residue (original residue number in PDB): E244 Q473
• Binding residue (residue number reindexed from 1): E216 Q445

Gene Ontology

Cellular Component

• GO:0005739 mitochondrion
• GO:0005763 mitochondrial small ribosomal subunit

External links

• PDB: RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
• PDBsum: 6hiw
• PubMed: 30213880
• UniProt: Q57YB5