Structure of PDB 4v8p Chain DA Binding Site BS01

Receptor Information

>4v8p Chain DA (length=91) Species: 5911 (Tetrahymena thermophila)

TRGTPAFGKRHQKTHTLCRRCGKATYHKQKLRCAACGYPDAKMRRYDGWG
QKVRDRKGQGTGRMRYMKTIARRAKNGFRSGTQAAPKVKAA

Ligand information

>4v8p Chain C2 (length=154)

agaaaauuuucaacgguggauaucuagguucccgugacgaugaagaacgc
agcgaaaugcgauacgcaaugcgaauugcagaaccgcgagucaucagauc
uuugaacgcaagugguggagguguaaaaaccuucauguuuguuucagugu
ggaa

............................................<<<<<<
.<<.....>>>.....(.<<<......>>............>>>..)...
>>>....<<.....>><<<<<<......>>>>>>................
....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v8p Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
• Resolution: 3.52 Å
• Binding residue (original residue number in PDB): T17 R20 R21 G23 K29 Y39 Q60 G61 T62 G63 R64 M65 R66 Y67 M68 K69 I71 R73 R74 A75 K76 N77 R80 T83 Q84 A85 P87 K88
• Binding residue (residue number reindexed from 1): T16 R19 R20 G22 K28 Y38 Q59 G60 T61 G62 R63 M64 R65 Y66 M67 K68 I70 R72 R73 A74 K75 N76 R79 T82 Q83 A84 P86 K87

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v8p, PDBe:4v8p, PDBj:4v8p
• PDBsum: 4v8p
• PubMed: 22052974
• UniProt: P0DJ24|RL37_TETTS Large ribosomal subunit protein eL37 (Gene Name=RPL37)