Structure of PDB 6gzz Chain D4 Binding Site BS01

Receptor Information
>6gzz Chain D4 (length=208) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRP
SDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRL
DNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEK
SRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQ
LVIEFYSR
Ligand information
>6gzz Chain A4 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<
.<<<..<<<..<<...........................>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<.<...
...>.>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....
.............>>>>>..>>>>>>>>>><<<....<<....<<<<<<<
.......>>>>>>>..>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<............>>>>>.<<........>>...>>>>>>
..........<<....<<<<....>>>>..>>....>.>>>>>>..<<<<
......<<<......>>>.....>>>>....<<<<<........<<<<..
...>>>>..........>>>>>......<<<<<(((...<<<<<.....<
..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((
.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>..>>>...>>>>...<<<....<....<<<<<
<....<<<<<<<....<<<......>>>.......>>>>>>>........
...<......>.>>>>>>...>.....>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>...)))..<.<<<.<
<<<<<<....<<<<<<....<<<<<<........<<........>>....
......<<<<...........<<<.........<<<....>>>.......
.................>>>....<.......<<<.<........<<<<<
<<<......>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<
<<...<...............>....>>>>>>>.....<<<<<....>>>
>>........>>>>..........>....>>>.....>......>>>.>.
....>>>>>>.......<<<<<.......<<<......<<........>>
........>>>.......>>>>>...........<<<<<<<........>
>>>>>>..........>>>>>>.....<<<<<............>>>>>.
...........>>>>>>>>>>..>............<<<<.<<<..<<<<
<<<<<<<<<...<.<<<.....<<......>>..>>>.>..>>>>>>>>>
>>>>..>>>.>>>>...............<<<<<<<<<....>>>>>>>>
>.....
Receptor-Ligand Complex Structure
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PDB6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.13 Å
Binding residue
(original residue number in PDB)
R3 I5 V8 R10 R14 K22 G23 E24 R25 K30 R35 R36 G41 Q42 H43 K46 Q62 S71 E72 R73 Q74 K84 K86 R115 Q119 R122 H123 H125 R132 V133 D134 L135 P136 S137 R139 K151 L155 E156 S208 R209
Binding residue
(residue number reindexed from 1)
R2 I4 V7 R9 R13 K21 G22 E23 R24 K29 R34 R35 G40 Q41 H42 K45 Q61 S70 E71 R72 Q73 K83 K85 R114 Q118 R121 H122 H124 R131 V132 D133 L134 P135 S136 R138 K150 L154 E155 S207 R208
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
PDBsum6gzz
PubMed30301898
UniProtP80373|RS4_THET8 Small ribosomal subunit protein uS4 (Gene Name=rpsD)

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