Structure of PDB 7tnq Chain D3 Binding Site BS01

Receptor Information

>7tnq Chain D3 (length=426) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MREIVHVQGGQCGNQIGAKFWEVISDEHGIDPTGTYCGDSDLQLERINVF
YNEATGGRFVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNN
WAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTL
LISKVREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQ
VIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCCLRFPGQLNSDL
RKLAVNLIPFPRLHFFLIGFAPLTSRGSQQYRALSVPELTQQMFDAKNMM
CASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNMK
SSVCDIPPKGLKMSVTFVGNSTAIQEMFKRVSDQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQ

Ligand information

>7tnq Chain 12 (length=22) Species: 508771 (Toxoplasma gondii ME49) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PTLPFNAQSCYRSEYVAKPLPP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tnq Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Resolution	8.4 Å
Binding residue (original residue number in PDB)	D26 L42 Q245 D355 I356 K359
Binding residue (residue number reindexed from 1)	D26 L42 Q245 D355 I356 K359

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005525	GTP binding

	Biological Process
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process

	Cellular Component
GO:0005737	cytoplasm
GO:0005874	microtubule

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Cellular Component

External links

PDB	RCSB:7tnq, PDBe:7tnq, PDBj:7tnq
PDBsum	7tnq
PubMed	35121661
UniProt	A0A125YWG5

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