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BioLiP

Structure of PDB 7r5k Chain D2 Binding Site BS01

Receptor Information
>7r5k Chain D2 (length=1312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSG
MSDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVF
PPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQP
HVRHLLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLP
TDNTYLLTITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKS
SLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVIQVYDLGQDG
QGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLL
AVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVH
RALYSKGILLMAASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSW
ALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSL
MFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTA
ACDREVSAWATRAFFRYGGEAQMRFPEIVYSGKHNGICIYFSRIMGNIWD
ASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEFLDRNSQFAG
GPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQ
AIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIR
DKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANE
LLQRSRQVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGV
VELSLTAAEKKDPQGLGLHFYKHGEPEEDIVGLQAFQERLNSYKCITDTL
QELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLSQR
SKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMD
LLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSST
AISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLD
SELMDITKLYGEFADPFKLAECKLAIIHCAGYSDPILVQTLWQDIIEKEL
SDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLN
WDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHV
LLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGN
FKSLQAKLERLH
Ligand information
>7r5k Chain U4 (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
IKKLVLKNLNNSNLFSPVN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r5k AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Resolution12.0 Å
Binding residue
(original residue number in PDB)		H1168 S1170 D1184 I1185 T1186 Y1189 P1195 F1196
Binding residue
(residue number reindexed from 1)		H1089 S1091 D1105 I1106 T1107 Y1110 P1116 F1117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore
Biological Process
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006998 nuclear envelope organization
GO:0015031 protein transport
GO:0034504 protein localization to nucleus
GO:0035196 miRNA processing
GO:0036228 protein localization to nuclear inner membrane
GO:0051028 mRNA transport
GO:0086014 atrial cardiac muscle cell action potential
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0044611 nuclear pore inner ring

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r5k, PDBe:7r5k, PDBj:7r5k
PDBsum7r5k
PubMed35679397
UniProtO75694|NU155_HUMAN Nuclear pore complex protein Nup155 (Gene Name=NUP155)

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