Structure of PDB 7r81 Chain D1 Binding Site BS01

Receptor Information
>7r81 Chain D1 (length=245) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRVIRNQRKGRGSIFTANTRLNKAPAKFRSLDYAERHGYIRGVVKEIIHD
PGRGAPLARVVFNSPYKFKKQRETFIANEGMYTGQFIYAGKNAALTVGNV
LPLGSVPEGTVVSNVEEKVGDRGAIGRTSGNYVTVVGHNPEEGKTRIKLP
SGAKKVVSSSARGMIGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRG
VAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLL
Ligand information
>7r81 Chain A1 (length=3123) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaauacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaaucuggcuucggcccgaguuguaauuugua
gaggaagcuuuuggugaggcaccuucugaguccccuggaacggggcgcca
uagagggugagagccccguauagucggaugccgauccaauguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcguuugugaccagacuugcgccguuccgaucauccg
guguucucaccggugcacucgggacggcucaggccagcaucgguuuuggc
ggggggauaaagguccggggaacguagcuccuccgggaguguuauagccc
cgggcguaaugcccucgccgggaccgagguucgcgcaucugcaaggaugc
uggcguaauggucaucaacgacccgucuugaaacacggaccaaggaguca
agguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagug
aacguaggugagagcuucggcgcaucaucgaccgauccugauguauucgg
auggauuugaguaagagcguuaagccuuggacccgaaagauggugaacua
ugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgg
uucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacua
aucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagca
guguuguucuucaguuuuaugagguaaagcgaaugauuagggaccauucu
caaacuuuaaauauguaagaagcccuuguuacuuaauugaacgugggcau
ucgaauguaccaacacuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucag
acaccacaaaaggcguuaguacaucuugacagcaggacgguggccaugga
agucggaauccgcuaaggacuguguaacaacucaccugccgaauguacua
gcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucag
gguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaa
gccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugg
uaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaaggu
uccaugugaacagcgguuggacauggguuagucgauccuaagccauaggg
aaguuccguuucaaaggggcagugccccguguggcgaaagggaagccggu
uaacauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacg
cggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacgg
ucuaucacccugaaaacaguuugucuggagauaggguuuaauggccggaa
gagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaa
uccgcgggagggaauaauucucacgccaggucguacucauaaccgcagca
ggucuccaaggugaacagccucugguugauagaacaauguagauaaggga
agucggcaaaauagauccguaacuucgggaaaaggauuggcucuaagggu
uggacaaccaacuuagaacugguacggacagggggaaucugacugucuaa
uuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugau
uucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcgg
guaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgu
caucuaauuagugacgcgcaugaauggauuaacgagauucccacuguccc
uaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaauc
agcggggaaagaagacccuguugagcuugacucuaguuugacauugugaa
aauuuuuuuacuuauucaauuaagcggggcuggauuuucguccaacuucu
gguuuuaagguccuucgcgggccgacccggguugaagacauugucaggug
gggaguuuggcuggggcggcacaucuguuaaaccauaacgcagguguccu
aaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaa
guccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggc
cuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaag
uuaccacagggauaacuggcuuguggcggccaagcguucauagcgacguc
gcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauu
cgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuu
agaccgucgugagacagguuaguuuuacccuacugaugaccucaucgcaa
ugguaauugagcuuaguacgagaggaaccgcucauucagauaauugguuu
uugcgguuguccgaccgggcagugccgcgacgcuaccaucugcuggauaa
uggcugaacgccucuaagucagaauccaugccagaacgcgaugauaccuc
cagcacguuguagacguauaagaauaggcuccggccucguaucuuagcag
gcgauuccuccguuggccuugaaguggccagcgguaauucgcguauugua
auuuuaacacgcgcuggaucaaauccuuugcagacgacuuagaugugcga
aaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggg
uaagcccuccuucgccuagauuu
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<.<<<<<.<<<...<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>.>>>>...>>>.....>>>>>.>
>>>........<<<<<<<........>>>>>>>.....<<<<<..(((((
(>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.....<<.<<<<<<<....<....<
<....>>....>........>>>.>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<<..>>>.....>>>
>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<
<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.
......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>.
..>>>.>>>.>>....>>>>.>>>>>>>>..<<.<..<<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<
<<<<<<.....<<.<<<<<<<.....<<<....<<<..<.<<.>>.>..>
>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>..
...>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<
..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.....
....>>...>>>.........<........>...>>>>>...>>>>>>>>
>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<
<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......
<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<
.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<
....>>>........<<<<<<.>>>>>>....>>>....>>...<<<<<.
.......>>>>>))<<<<.<<<<.<<<....<<<....>>>......(<<
<<<<...<<<<.<<<<<<<<<<<<<.<<<<.......>>>>.><...<<<
<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>...
.><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........
>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......
>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<..
.......<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<
<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<....
.....>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...
<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.
>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<
<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<
<....>>>>>>...<<<<<.....<<<<..<<<<......>>>>......
....)...<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>.
.>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<.
..<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....
>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)
))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>
>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>
>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>
>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<..
<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<..
..<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...
<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>....<<
<<<<.<<<.<<......<<.......<<<....>>>....>>........
<<<<.....<<<<<<<<<.......>>>>>>>>>....>>>>........
......>>>>>.>>>>>>..<<.<.<<.............>>....<.<<
.<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>
....>>>>..>>..>...>.>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r81 Structure of the translating Neurospora ribosome arrested by cycloheximide
Resolution2.7 Å
Binding residue
(original residue number in PDB)
G2 R3 V4 N7 Q8 R9 K10 G11 R12 S14 I15 A18 N19 T20 R21 L22 K24 A25 P26 S31 Y34 R37 G39 Y40 H50 P52 R54 Y67 F69 R73 T84 G85 F87 Y89 A94 A95 E118 R123 A125 I126 G127 R128 T129 S130 G131 N132 L150 S152 K156 R174 T175 K177 L179 L180 K181 A182 S183 A185 K186 H187 K192 R193 N194 W196 P197 T199 R200 G201 V202 M204 N205 P206 V207 D208 H209 H211 G213 G214 N215 H216 Q217 H218 I219 G220 K221 A222 S223 T224 S226 R227 A230 Q231 G232 Q233 K234 A235 G236 I238 A240 R241 R242 T243 G244 L245 L246
Binding residue
(residue number reindexed from 1)
G1 R2 V3 N6 Q7 R8 K9 G10 R11 S13 I14 A17 N18 T19 R20 L21 K23 A24 P25 S30 Y33 R36 G38 Y39 H49 P51 R53 Y66 F68 R72 T83 G84 F86 Y88 A93 A94 E117 R122 A124 I125 G126 R127 T128 S129 G130 N131 L149 S151 K155 R173 T174 K176 L178 L179 K180 A181 S182 A184 K185 H186 K191 R192 N193 W195 P196 T198 R199 G200 V201 M203 N204 P205 V206 D207 H208 H210 G212 G213 N214 H215 Q216 H217 I218 G219 K220 A221 S222 T223 S225 R226 A229 Q230 G231 Q232 K233 A234 G235 I237 A239 R240 R241 T242 G243 L244 L245
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7r81, PDBe:7r81, PDBj:7r81
PDBsum7r81
PubMed34815343
UniProtQ7RVQ9

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