Structure of PDB 8z9a Chain D Binding Site BS01

Receptor Information

>8z9a Chain D (length=357) Species: 7029 (Acyrthosiphon pisum)

IDTINMFLQMTGCTDSKAMLYLTYFEFLITFYYLIATYASIVHFEQSVTI
QLFALLCMLIECVILLNITFRLYHKNHIREMHQYSRRLGIPDSYRSVINV
ITKYHLIASNIFVVFPVTYAIFCDSVRVGDPFTFPFLDVLPMHTDNLAIY
ACKYLVYAISVYIAHVELCFINTTFIYYVGVLKHRLETIVQTIGEAFADN
DEQKFKYAIIQHQKLLSYFNTMKIVFSKPILLSMSFNAIYFGLTTSFVIQ
AIRGYINQAILSICIASSAAAVINITIYTFYGSELMDLHDKILHVLFDNA
FFYVSKSFKSSILIMMTRVTIPLKFTVGYIFTINLNLLLKILKMSYTVLN
VLLSSET

Ligand information

• Ligand ID: SOU
• InChI: InChI=1S/C12H20O2/c1-10(2)6-5-7-11(3)8-9-14-12(4)13/h6,8H,5,7,9H2,1-4H3/b11-8+
• InChIKey: HIGQPQRQIQDZMP-DHZHZOJOSA-N
• SMILES:
  CACTVS 3.385: CC(=O)OC\C=C(/C)CCC=C(C)C
  OpenEye OEToolkits 2.0.7: CC(=CCCC(=CCOC(=O)C)C)C
  OpenEye OEToolkits 2.0.7: CC(=CCC/C(=C/COC(=O)C)/C)C
  CACTVS 3.385: CC(=O)OCC=C(C)CCC=C(C)C
• Formula: C12 H20 O2
• Name: [(2E)-3,7-dimethylocta-2,6-dienyl] ethanoate
• PDB chain: 8z9a Chain D Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8z9a Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): I63 V164 A269 S270
• Binding residue (residue number reindexed from 1): I60 V161 A266 S267
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004984 olfactory receptor activity

Biological Process

• GO:0007165 signal transduction
• GO:0007608 sensory perception of smell
• GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8z9a, PDBe:8z9a, PDBj:8z9a
• PDBsum: 8z9a
• PubMed: 38870272
• UniProt: A0A1S6J146