Structure of PDB 8x83 Chain D Binding Site BS01

Receptor Information
>8x83 Chain D (length=380) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEISQPSIGIFYISKVLALAPYATVRNSKGRVEIGRSWLFTVYSATLTVV
MVFLTYRGLLFDANSEIPVRMKSATSKVVTALDVSVVVMAIVSGVYCGLF
SLNDTLELNDRLNKIDNTLNAYNNFRRDRWRALGMAAVSLLAISILVGLD
VGTWMRIAQDMNIAQSDTELNVHWYIPFYSLYFILTGLQVNIANTAYGLG
RRFGRLNRMLSSSFLAAAAKNKGLLLKSLADSHESLGKCVHLLSNSFGIA
VLFILVSCLLHLVATAYFLFLELLSKRDNGYLWVQMLWICFHFLRLLMVV
EPCHLAARESRKTIQIVCEIERKVHEPILAEAVKKFWQQLLVVDADFSAC
GLCRVNRTILTSFASAIATYLVALIQFQRT
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain8x83 Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8x83 Structural basis for sugar perception by Drosophila gustatory receptors.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R70 D83 F178 Y182 H306 T310 F313 Q330 W333 H337
Binding residue
(residue number reindexed from 1)		R70 D83 F178 Y182 H261 T265 F268 Q285 W288 H292
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008527 taste receptor activity
GO:0033041 sweet taste receptor activity
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0170023 ionotropic sweet taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007635 chemosensory behavior
GO:0008049 male courtship behavior
GO:0008343 adult feeding behavior
GO:0032098 regulation of appetite
GO:0050909 sensory perception of taste
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0050916 sensory perception of sweet taste
GO:0060259 regulation of feeding behavior
GO:0071332 cellular response to fructose stimulus
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x83, PDBe:8x83, PDBj:8x83
PDBsum8x83
PubMed38305684
UniProtQ9V4K2|GR43A_DROME Gustatory receptor for sugar taste 43a (Gene Name=Gr43a)

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