Structure of PDB 8x6g Chain D Binding Site BS01

Receptor Information
>8x6g Chain D (length=1176) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIF
GPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVS
HIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSE
AEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQR
LTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMVQLDGGRFATS
DLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRG
RPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKM
YQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLE
EVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDG
DQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYL
TLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEE
QNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRYFIDPTTLG
EGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGF
KFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERY
NAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMR
GLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSG
YLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYS
KETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGV
CEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTQGLPRIQEIFEAR
NPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVE
IGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQKVYRMQGVEID
DKHVEVMVRQMLRKVRIIEAGDTKLLPGSLVDIHNFTDANREAFKHRKRP
ATAKPVLLGITKASLETESFLSAASFQETTRVLTDAAIKGKRDDLLGLKE
NVIIGKLIPAGTGMRRYSDVKYEKTA
Ligand information
>8x6g Chain T (length=40) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cttttgattctacccgttttacatgggctttaaactcatt
Receptor-Ligand Complex Structure
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PDB8x6g Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q1144 E1145
Binding residue
(residue number reindexed from 1)		Q1127 E1128
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x6g, PDBe:8x6g, PDBj:8x6g
PDBsum8x6g
PubMed38844782
UniProtQ2G0N5|RPOC_STAA8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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