Structure of PDB 8wqh Chain D Binding Site BS01

Receptor Information
>8wqh Chain D (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPL
IIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGH
FEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIA
NKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHI
DIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRI
EALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH
AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYR
GAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNE
TVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYL
VCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDD
FHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFL
TLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL
AARAVRANDINYQDQIPRTLEEFVGFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8wqh cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)
Resolution3.44 Å
Binding residue
(original residue number in PDB)		R264 Y349 D356 V391 Q394
Binding residue
(residue number reindexed from 1)		R264 Y349 D356 V391 Q394
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0002070 epithelial cell maturation
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0031462 Cul2-RING ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8wqh, PDBe:8wqh, PDBj:8wqh
PDBsum8wqh
PubMed38670995
UniProtQ9UK73|FEM1B_HUMAN Protein fem-1 homolog B (Gene Name=FEM1B)

[Back to BioLiP]