Structure of PDB 8v6n Chain D Binding Site BS01

Receptor Information
>8v6n Chain D (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVFSKPMDSNIRQCRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDED
VPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRF
INAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPK
YQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHAL
VTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGK
AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSV
LEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNI
TLTLVSYYRPREEEGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQS
ILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY
TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKD
NKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILT
FVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRF
RMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNE
Ligand information
Ligand IDACD
InChIInChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-
InChIKeyYZXBAPSDXZZRGB-DOFZRALJSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CCCCC/C=C\C\C=C/C/C=C\C\C=C/CCCC(O)=O
ACDLabs 10.04O=C(O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
OpenEye OEToolkits 1.5.0CCCCCC=CCC=CCC=CCC=CCCCC(=O)O
OpenEye OEToolkits 1.5.0CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
CACTVS 3.341CCCCCC=CCC=CCC=CCC=CCCCC(O)=O
FormulaC20 H32 O2
NameARACHIDONIC ACID
ChEMBLCHEMBL15594
DrugBankDB04557
ZINCZINC000004474696
PDB chain8v6n Chain D Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8v6n TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Resolution2.59 Å
Binding residue
(original residue number in PDB)		I528 S576 I579 Q580
Binding residue
(residue number reindexed from 1)		I413 S461 I464 Q465
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8v6n, PDBe:8v6n, PDBj:8v6n
PDBsum8v6n
PubMed38691614
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

[Back to BioLiP]