Structure of PDB 8v6j Chain D Binding Site BS01

Receptor Information
>8v6j Chain D (length=381) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDPASLPDVLPLYYRRLFPFYQYFRWLNYGGVVKNYFQHREFSFTLKDDV
YVRYQSFNNQSELEKEMQKMCPYKIDIGAVYSHRPSLHNTVKSGTFQAQE
KELVFDIDMTDYDDVRRCCSSADICPKCWTLMTIAVRILDRALAEDFGFK
HRLWVYSGRRGVHCWVCDDSARKLSQAERSAVAEYLSVVKGGEETIKKVQ
LPETIHPFIGKSLKMVERYFEKYALVDQDILENKQCWDKVIALVPEVARE
SLLREFSKARSSVERWDKLSSCLEATRRYSNIPKEIMLQFCYPRLDVNVS
KGLNHLLKSPFSVHPKTGRISVPIDCKKLDQFDPFSVPTISLICSELDNV
RTRDYKRTSLAPYIKVFEQFLDKLDQSRKGE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8v6j Chain D Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v6j A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase
Resolution11.11 Å
Binding residue
(original residue number in PDB)		C123 C124 C130 C133
Binding residue
(residue number reindexed from 1)		C118 C119 C125 C128
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Molecular Function
GO:0003896 DNA primase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006269 DNA replication, synthesis of primer
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v6j, PDBe:8v6j, PDBj:8v6j
PDBsum8v6j
PubMed38491139
UniProtQ800A4

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