Structure of PDB 8v02 Chain D Binding Site BS01

Receptor Information

>8v02 Chain D (length=375) Species: 7159 (Aedes aegypti)

MASILDCPIVSVNARVWRFWSFVLKHDAMRYISIIPVTVMTFFMFTDLCR
SWGNIQELIIKAYFAVLYFNAVLRTLILVKDRKLYENFMQGISNVYFEIS
HIDDHKIQSLLKSYTVRARMLSISNLALGAIISTCFVVYPIFTGERGLPY
GMFIPGLDSFRSPHYEIIYIVQVVLTFPGCCMYIPFTSFFASTTLFGLVQ
IKTLQRQLQTFKDNINSQDKEKVKAKVVKLIEDHKRIITYVSELNSLVTY
ICFVEFLSFGMMLCALLFLLNVIENHAQIVIVAAYIFMIISQIFAFYWHA
NEVREESMNLAEAAYSGPWVELDNSIKKKLLLIILRAQQPLEITVGNVYP
MTLEMFQSLLNASYSYFTLLRRVYN

Ligand information

• Ligand ID: JZ0
• InChI: InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3
• InChIKey: QWVGKYWNOKOFNN-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.352
  OpenEye OEToolkits 1.7.0: Cc1ccccc1O
• Formula: C7 H8 O
• Name: o-cresol;
  ortho-cresol,2-methylphenol
• ChEMBL: CHEMBL46931
• ZINC: ZINC000000901022
• PDB chain: 8v02 Chain D Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8v02 Structural basis of odor sensing by insect heteromeric odorant receptors.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): L67 Y68 I132 S133 F136 C180 Y183
• Binding residue (residue number reindexed from 1): L67 Y68 I132 S133 F136 C180 Y183
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004984 olfactory receptor activity

Biological Process

• GO:0007165 signal transduction
• GO:0007608 sensory perception of smell
• GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8v02, PDBe:8v02, PDBj:8v02
• PDBsum: 8v02
• PubMed: 38870275
• UniProt: Q177X3