Structure of PDB 8u17 Chain D Binding Site BS01

Receptor Information
>8u17 Chain D (length=349) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRT
QSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPSYKWWQKYQK
RKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPID
FSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQET
EITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHS
WFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8u17 Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8u17 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C323 C326 C391 C394
Binding residue
(residue number reindexed from 1)		C244 C247 C312 C315
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8u17, PDBe:8u17, PDBj:8u17
PDBsum8u17
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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