Structure of PDB 8tzx Chain D Binding Site BS01
Receptor Information
>8tzx Chain D (length=341) Species:
9606
(Homo sapiens) [
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DSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAY
SNAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSYKWWQKYQKRKFHCAN
LTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAA
CLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNE
IFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAW
TVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP
Ligand information
>8tzx Chain F (length=26) Species:
9606
(Homo sapiens) [
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SLTTCEVCGACFETRKGLSSHARSHL
Receptor-Ligand Complex Structure
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PDB
8tzx
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Resolution
3.15 Å
Binding residue
(original residue number in PDB)
N351 H353 Y355 H357 W386 V388 Q390 H397 W400
Binding residue
(residue number reindexed from 1)
N265 H267 Y269 H271 W300 V302 Q304 H311 W314
External links
PDB
RCSB:8tzx
,
PDBe:8tzx
,
PDBj:8tzx
PDBsum
8tzx
PubMed
38963839
UniProt
Q96SW2
|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)
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