Structure of PDB 8szt Chain D Binding Site BS01

Receptor Information

>8szt Chain D (length=363) Species: 470 (Acinetobacter baumannii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KIGYVWDTLYSWVDTGTGGVFAANLSKRIQPITHHMNHPDTKRRFNELVM
TSGQIDFLTPIKPYPATDADILRVHDKQLLDNAKNVSNKECGGDIGDRVT
HLGNGGIEIAYLSAGGAIELTKKVISGELHTGYALVSPPGHHATKKDSMG
FCIFNNTSIAAAYAKDILGLKRVAIVDWDVHHGNGTQDIWWEDSSVLTIS
IHQNKCFPTNSGFINERGAGNGFGYNLNIPLPPGSGNGAYIYAFEKVIVP
ALKKYEPELIIVGSGFDASILDPLSRMMVSSEGFKKMASLILEVSNEING
GKCLFVQEGGYSPHYLPFCGLAVIEALTGMHTLDDPLIDGGNELLPHEKK
VVDECANLIADIN

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8szt Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8szt Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii .
Resolution	2.5 Å
Binding residue (original residue number in PDB)	D181 H183
Binding residue (residue number reindexed from 1)	D179 H181
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004407	histone deacetylase activity
GO:0046872	metal ion binding

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0006338	chromatin remodeling

	Cellular Component
GO:0005737	cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8szt, PDBe:8szt, PDBj:8szt
PDBsum	8szt
PubMed	37624144
UniProt	R8YPJ7

[Back to BioLiP]