Structure of PDB 8soj Chain D Binding Site BS01

Receptor Information

>8soj Chain D (length=490) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLI
QDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKL
QSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLT
ANQHSDVICQSEPDDSFPSSGSESDLVSLYEVERCQQLSATILTDHQYLE
RTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHE
GDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGI
LPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAPFLI
QGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVM
TFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPG
IKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8soj Chain D Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8soj Structural basis of CST-Pol alpha /Primase recruitment and regulation by POT1 at telomeres.
Resolution	3.8 Å
Binding residue (original residue number in PDB)	C382 C503
Binding residue (residue number reindexed from 1)	C238 C359
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0043047	single-stranded telomeric DNA binding

	Biological Process
GO:0000723	telomere maintenance

	Cellular Component
GO:0000781	chromosome, telomeric region

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8soj, PDBe:8soj, PDBj:8soj
PDBsum	8soj
PubMed	37215005
UniProt	Q9NUX5\|POTE1_HUMAN Protection of telomeres protein 1 (Gene Name=POT1)

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