Structure of PDB 8rqc Chain D Binding Site BS01

Receptor Information
>8rqc Chain D (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTSHTYLGADMEEFGRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHP
QEVSMVRNLIQNDRTFAVLAYSNVEREAEFGTTAEIYAYREEQDFGIEIV
KVKAIGRQRFKVLELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLRE
WDENLKDDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELD
IMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVY
KACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQK
FWGLTRSALIPT
Ligand information
>8rqc Chain E (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PFQCNQCGASFTQKGNLLRHIKLHSGE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rqc Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Resolution2.15 Å
Binding residue
(original residue number in PDB)		N351 H353 Y355 W386 V388 A395 H397 W400
Binding residue
(residue number reindexed from 1)		N238 H240 Y242 W273 V275 A282 H284 W287
External links
PDB RCSB:8rqc, PDBe:8rqc, PDBj:8rqc
PDBsum8rqc
PubMed
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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