Structure of PDB 8qu5 Chain D Binding Site BS01

Receptor Information
>8qu5 Chain D (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANFVSWKSRTKYTITPVKMRKSGGRDHTGRIRVHGIGGGHKQRYRMIDFL
RFRPEETKSGPFEEKVIQVRYDPCRSADIALVAGGSRKRWIIATENMQAG
DTILNSNHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAA
GTCGVLLRKVNGTAIIQLPSKRQMQVLETCVATVGRVSNVDHNKRVIGKA
GRNRWLGKRPNSLPPMKSYV
Ligand information
>8qu5 Chain A (length=1049) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcgccuggugauagcugguugucc
aagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaaucccc
uuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagg
aaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaa
aagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacaua
uaacugaacuccucacacccaauuggaccaaucuaucacccuauagaaga
acuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccug
cgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacaggcaugcucauaaggaaaggu
uaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggc
cagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcggg
cauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaa
caccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaacc
uccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauuga
uccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauu
ccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgcc
uucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu
<<<.......<<<<..................................<.
.....>...........<<.....>>.......>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<....>.>>>>......>.>>..<<<<
<<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>...
..>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<
......>>>....<<<.<<<...<..............<....<<<....
.....>>>....>.......<<<......>>>..................
....>...>>>>>>........>>>>>>...<<<<<......>>>>>...
......>>>>>><......<<..<<<....>>><<<<..<<<<.......
.<<<<<....>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<
<...<<<<<<<<.<<.........<<<<<<.............>>>>>>.
.......>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>
>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<..
....>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.......
..<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<
.<<<.................>>>.>>><<<<<...<<<....>>>.>>>
>>.<<<.<............>.>>>........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qu5 GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution2.42 Å
Binding residue
(original residue number in PDB)
W66 K67 R69 K71 T75 S82 G84 H87 R92 V93 H100 K101 Q102 R103 Y104 R105 I127 Q128 R130 Y131 P133 R135 L141 K148 W150 R202 Q205 Y206 I207 R208 A209 A210 G211 L228 P229 S230 R232 R246 H252 N253 I257 G258 R262 N263 W265 L266 P270 N271 S272 K293 Y295
Binding residue
(residue number reindexed from 1)
W6 K7 R9 K11 T15 S22 G24 H27 R32 V33 H40 K41 Q42 R43 Y44 R45 I67 Q68 R70 Y71 P73 R75 L81 K88 W90 R142 Q145 Y146 I147 R148 A149 A150 G151 L168 P169 S170 R172 R186 H192 N193 I197 G198 R202 N203 W205 L206 P210 N211 S212 K217 Y219
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8qu5, PDBe:8qu5, PDBj:8qu5
PDBsum8qu5
PubMed38969660
UniProtQ5T653|RM02_HUMAN Large ribosomal subunit protein uL2m (Gene Name=MRPL2)

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