Structure of PDB 8qrm Chain D Binding Site BS01

Receptor Information
>8qrm Chain D (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFFTKLTADELWKGALAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRY
GFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQREEWDRKKKKRE
RGWSGNSWGGISLGPPDPGPCGETYEDFDTRILEVRNVFTMTAKEGRKKS
IRVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAVHHLHYIERYEDHTI
FHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYAKVSGSI
NMLSLTQGLFRGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASPRGP
LRKDPEPEDEVPDVKLDWEDVKTAQGMKRSVWSNLKRAAT
Ligand information
>8qrm Chain A (length=955) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaug
caagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaa
gggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagc
cacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaag
uuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccac
cgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguu
uuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaa
acuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaa
cacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuag
cccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacg
agccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuag
aggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuug
cucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaag
uaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugag
guggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccu
uaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagag
ugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuc
cucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauau
agaggagacaagucguaacaugguaaguguacuggaaagugcacuuggac
gaacc
...((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<
<..<......>......<<.......<<<<.<..<<.......>>.>..>
>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>
.>>.<<......>>.....>>>>>>>........<<<....<<<<....>
>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>
>)).......)))..>>>>>...>.>>>>>>....<<<((.....<<<<.
.<<<<...............<<<<<<......<<<.<<<.<<<......>
>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<
<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<....<<<.<<<<
<..<<<<<<<<<<.....<<........>>..........<<<<<<<...
....<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>
>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>
>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<
<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.......
..>>>>>>>.....>>>....>>>>>>>>>.>>....<..<<.<...<<<
<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>
.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>....
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qrm GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution3.05 Å
Binding residue
(original residue number in PDB)
T91 K100 G101 A104 T106 G109 K111 K112 R114 R191 S194 G195 N196 R226 T230 M231 A233 K234 E235 F256 K260 R269 K270 R274 R297 F298 K299 R300 R315 C316 H317 R318 A334 K335 S339 I340 L343 Q347 W408 K418 R419 S420 V421 W422 S423 R427
Binding residue
(residue number reindexed from 1)
T4 K13 G14 A17 T19 G22 K24 K25 R27 R101 S104 G105 N106 R136 T140 M141 A143 K144 E145 F166 K170 R179 K180 R184 R207 F208 K209 R210 R225 C226 H227 R228 A244 K245 S249 I250 L253 Q257 W318 K328 R329 S330 V331 W332 S333 R337
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8qrm, PDBe:8qrm, PDBj:8qrm
PDBsum8qrm
PubMed38969660
UniProtP82675|RT05_HUMAN Small ribosomal subunit protein uS5m (Gene Name=MRPS5)

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