Structure of PDB 8qj7 Chain D Binding Site BS01

Receptor Information
>8qj7 Chain D (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQ
SKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFI
QQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSP
SLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNE
FRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQGNVGKI
SLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLE
QALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKII
LSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQ
VACQKYFEMIHNVDDCGFSLNHPNQFFCESQRIL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8qj7 Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8qj7 CryoEM insights into RNA primer synthesis by the human primosome.
Resolution3.07 Å
Binding residue
(original residue number in PDB)		P285 P286 C287 C367 I370 C384 C424 L441
Binding residue
(residue number reindexed from 1)		P264 P265 C266 C346 I349 C363 C403 L420
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:1903934 positive regulation of DNA primase activity
Cellular Component
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qj7, PDBe:8qj7, PDBj:8qj7
PDBsum8qj7
PubMed38335062
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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