Structure of PDB 8ovh Chain D Binding Site BS01

Receptor Information
>8ovh Chain D (length=400) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPSHFDTVQLHAGQENSRAVPIYATTSYNPTSNVLEERIAALEGGAAALA
VSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFV
EGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVV
DNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKD
YPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFAS
FLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHEN
AKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANV
GDAKTLVIAPYFTTGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8ovh Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ovh Enzymatic Synthesis of l-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade.
Resolution2.171 Å
Binding residue
(original residue number in PDB)		G86 Q87 Q90 Y111 D183 F186 S206 T208 K209
Binding residue
(residue number reindexed from 1)		G54 Q55 Q58 Y79 D151 F154 S174 T176 K177
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.47: cysteine synthase.
2.5.1.49: O-acetylhomoserine aminocarboxypropyltransferase.
Gene Ontology
Molecular Function
GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding
GO:0051009 O-acetylhomoserine sulfhydrylase activity
Biological Process
GO:0000103 sulfate assimilation
GO:0006520 amino acid metabolic process
GO:0006535 cysteine biosynthetic process from serine
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0071266 'de novo' L-methionine biosynthetic process
GO:0071269 L-homocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ovh, PDBe:8ovh, PDBj:8ovh
PDBsum8ovh
PubMed37235813
UniProtP06106|CYSD_YEAST Homocysteine/cysteine synthase (Gene Name=MET17)

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