Structure of PDB 8oi6 Chain D Binding Site BS01

Receptor Information

>8oi6 Chain D (length=354) Species: 9913 (Bos taurus)

AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVQKDSYVGDEA
QSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEA
PLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDG
VTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREI
VRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPG
IADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEY

Ligand information

>8oi6 Chain J (length=7) Species: 67723 (Amanita phalloides)

WLATCPA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8oi6 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments.
• Resolution: 3.59 Å
• Binding residue (original residue number in PDB): T194 G197 Y198 S199 Q246
• Binding residue (residue number reindexed from 1): T186 G189 Y190 S191 Q238

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0019901 protein kinase binding
• GO:0098973 structural constituent of postsynaptic actin cytoskeleton

Biological Process

• GO:0007409 axonogenesis
• GO:0048870 cell motility
• GO:0098974 postsynaptic actin cytoskeleton organization

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0005884 actin filament
• GO:0005886 plasma membrane
• GO:0005925 focal adhesion
• GO:0015629 actin cytoskeleton
• GO:0016020 membrane
• GO:0030424 axon
• GO:0032991 protein-containing complex
• GO:0035267 NuA4 histone acetyltransferase complex
• GO:0045202 synapse
• GO:0097433 dense body

External links

• PDB: RCSB:8oi6, PDBe:8oi6, PDBj:8oi6
• PDBsum: 8oi6
• PubMed: 37749275
• UniProt: P60712|ACTB_BOVIN Actin, cytoplasmic 1 (Gene Name=ACTB)