Structure of PDB 8itp Chain D Binding Site BS01

Receptor Information
>8itp Chain D (length=341) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPVDENGHRYVGLVNQAMTSYLNSLVQSLYMTPEFRNAMYDWERKKAEQS
IPCQLQKLFLLLQTSENDSLETKDLTQSFGWTSHDVQELCRLMFDALEHK
WKGTEHEKLIQDLYRGTMEDFVACLKCGRESVKTDYFLDLPLAVKPFGAI
HAYKSVEEALTAFVQPELLDGSNQYMCENCKSKQDAHKGLRITQFPYLLT
IQLKRFDFDYNTMHRIKLNDKMTFPDVLDLNDYVNVCVGQPIDHAAVDDI
VKTSGDNVYELFSVMVHSGNAAGGHYFAYIKNLDQDRWYVFNDTRVDFAT
PLEIEKSFGGHSNTNAYMLMYRRIDPKRNARFILSNQLPQH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8itp Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8itp Structural and functional characterization of USP47 reveals a hot spot for inhibitor design
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C218 C221 C271 C274
Binding residue
(residue number reindexed from 1)		C124 C127 C177 C180
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:8itp, PDBe:8itp, PDBj:8itp
PDBsum8itp
PubMed37740002
UniProtQ22240

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