Structure of PDB 8ipm Chain D Binding Site BS01

Receptor Information
>8ipm Chain D (length=282) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAY
ALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSM
QLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRT
YGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQ
RSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLE
DRIVKRFLLGISMLMWELIHKKVAKLRAAIKL
Ligand information
>8ipm Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LCGIDHEALNKQIMEYKRRKD
Receptor-Ligand Complex Structure
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PDB8ipm Structural insights reveal the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12S rRNA by methyltransferase METTL15
Resolution3.1 Å
Binding residue
(original residue number in PDB)		P136 D140 N143 A144 L145 Y157 F222 N225
Binding residue
(residue number reindexed from 1)		P130 D134 N137 A138 L139 Y151 F216 N219
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ipm, PDBe:8ipm, PDBj:8ipm
PDBsum8ipm
PubMed38291322
UniProtA6NJ78|MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (Gene Name=METTL15)

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