Structure of PDB 8i9o Chain D Binding Site BS01

Receptor Information
>8i9o Chain D (length=526) Species: 866768 (Escherichia coli 'BL21-Gold(DE3)pLysS AG') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGT
MSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLR
KERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESL
PFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSI
GIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLL
KSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIEL
PDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPG
GFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANS
TEFVPDCKYPVVALITEWRTMRLGAQQCQLVDDSLVRQLYNAPTIVERHR
HRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEF
TSTPRDGHPLFAGFVKAASEFQKRQA
Ligand information
Ligand IDCTP
InChIInChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyPCDQPRRSZKQHHS-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.341NC1=NC(=O)N(C=C1)[CH]2O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]2O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC2OC(N1C(=O)N=C(N)C=C1)C(O)C2O
CACTVS 3.341NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]2O
FormulaC9 H16 N3 O14 P3
NameCYTIDINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL223533
DrugBankDB02431
ZINCZINC000003861746
PDB chain8i9o Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8i9o Filamentation and inhibition of prokaryotic CTP synthase
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Q114 I116
Binding residue
(residue number reindexed from 1)		Q113 I115
Annotation score4
Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003883 CTP synthase activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0097268 cytoophidium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i9o, PDBe:8i9o, PDBj:8i9o
PDBsum8i9o
PubMed38948148
UniProtP0A7E5|PYRG_ECOLI CTP synthase (Gene Name=pyrG)

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