Structure of PDB 8hkf Chain D Binding Site BS01

Receptor Information
>8hkf Chain D (length=899) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSS
SEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFR
VSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRS
AMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTV
GYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKQTEKHVV
LCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLW
SQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRA
WAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPA
TSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREY
EGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYI
NITKEENSAFIFKQEEKRKIAPVLELAVEYVKGYPPNSPYIGSSPTLCHL
LPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
PLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSL
LQCGIIYADNLVVVDKEAEEDYMADAKTIVNVQTMFRLFPSLSITTELTH
PSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSIS
MLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYG
RLFQKLCSSSAEIPIGIYRTESHVFAAAEWISQQRLSLYRRSERQELSEL
VKNRMKHLGLPTTGYDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hkf Chain D Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hkf Structural basis of human Slo2.2 channel gating and modulation.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		C785 H787
Binding residue
(residue number reindexed from 1)		C566 H568
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hkf, PDBe:8hkf, PDBj:8hkf
PDBsum8hkf
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

[Back to BioLiP]