Structure of PDB 8h2h Chain D Binding Site BS01

Receptor Information
>8h2h Chain D (length=599) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKPTMAILERISKNSQENIDEVFTRLYRYLLRPDIYYVAYQNLYSNKGAS
TKGILDDTADGFSEEKIKKIIQSLKDGTYYPQPVRRMYIAKKNSKKMRPL
GIPTFTDKLIQEAVRIILESIYEPVFEDVSHGFRPQRSCHTALKTIKREF
GGARWFVEGDIKGCFDNIDHVTLIGLINLKIKDMKMSQLIYKFLKAGYLE
NWQYHKTYSGTPQGGILSPLLANIYLHELDKFVLQLKMKFDRESPERITP
EYRELHNEIKRISHRLKKLEGEEKAKVLLEYQEKRKRLPTLPCTSQTNKV
LKYVRYADDFIISVKGSKEDCQWIKEQLKLFIHNKLKMELSEEKTLITHS
SQPARFLGYDIRVRRSGTIKRSGKVKKRTLNGSVELLIPLQDKIRQFIFD
KKIAIQKKDSSWFPVHRKYLIRSTDLEIITIYNSELRGICNYYGLASNFN
QLNYFAYLMEYSCLKTIASKHKGTLSKTISMFKDGSGSWGIPYEIKQGKQ
RRYFANFSECKSPYQFTDEISQAPVLYGYARNTLENRLKAKCCELCGTSD
ENTSYEIHHVNKVKNLKGKEKWEMAMIAKQRKTLVVCFHCHRHVIHKHK
Ligand information
>8h2h Chain A (length=692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcgcccagauaggguguuaagucaaguaguuuaagguacuacucugua
agauaacacagaaaacagccaaccuaaccgaaaagcgaaagcugauacgg
gaacagagcacgguuggaaagcgaugaguuaccuaaagacaaucggguac
gacugagucgcaauguuaaucagauauaagguauaaguuguguuuacuga
acgcaaguuucuaauuucgguuaugugucgauagaggaaagugucugaaa
ccucuaguacaaagaaagguaaguuaugguuguggacuuaucuguuauca
ccacauuuguacaaucuguaggagaaccuaugggaacgaaacgaaagcga
ugccgagaaucugaauuuaccaagacuuaacacuaacuggggauacccua
aacaagaaugccuaaaggaggaaaaaggcuauagcacuagagcuugaaaa
ucuugcaaggguacggaguacucguaguagucugagaaggguaacgcccu
uuacauggcaaagggguacaguuauuguguacuaaaauuaaaaauugauu
agggaggaaaaccucaaaccaacaauggcaauuuuagacaauaacagagc
cguauacuccgagagggguacguacgguucccgaagaggguggugcaaac
cagucacaguaaugugaacaaggcgguaccucccuacuucac
..[..<<<<<....<<<<<<<<<<<..<<<<<.......>>>>><<<<..
...((((.>>>>.<<<<.<<<<<<...<...<<.<<....>>>..>..>.
........]..>>>>>>...<<<<....<.......(((...........
.>.....>>>>..>>>>...<<<<.....<<<<<.<<<.......>>>..
.<<<..<<.<........<.........>..............)))....
........<<<<<<...<<<<<<<<.........>>>>>>>>.))))...
...>.>>>>>........<<<......>>>.........>>>....>>>>
>>>>.....>>>>..........>>>>>>>>>>>..>>>>>...<<<...
...<.......<....>..........<<<...<..>...>>>.......
..>.....>>.>.....<<<<<.............<<<<<.......>>>
>>...........>>.>>>.<<<<<<<................<<.....
........................>>............>>>>>>>.<<<<
<<<<<<<<<<....>>>>>..>>>>>>>>>..<<<<<<<<..<<<.....
.......<....>.............>>>..>>>>.>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h2h Functionalized graphene grids with various charges for single-particle cryo-EM.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		M1 K2 I7 R10 N14 R25 R32 K75 D76 Y80 R154 W155 K185 K195 H349 R365 R395 Q406 K408 N453 Y454 S486
Binding residue
(residue number reindexed from 1)		M1 K2 I7 R10 N14 R25 R32 K75 D76 Y80 R154 W155 K185 K195 H349 R365 R395 Q406 K408 N453 Y454 S486
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006314 intron homing
GO:0006397 mRNA processing
GO:0006974 DNA damage response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8h2h, PDBe:8h2h, PDBj:8h2h
PDBsum8h2h
PubMed36344519
UniProtP0A3U0|LTRA_LACLC Group II intron-encoded protein LtrA (Gene Name=ltrA)

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