Structure of PDB 8g5h Chain D Binding Site BS01

Receptor Information
>8g5h Chain D (length=318) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTI
DIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWI
TTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGY
PREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS
VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVL
TMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYMDSYA
RIFFPTAFCLFNLVYWVS
Ligand information
Ligand IDR5R
InChIInChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1ccc(cc1)c2c(n3cc(ccc3n2)C)CC(=O)N(C)C
CACTVS 3.385CN(C)C(=O)Cc1n2cc(C)ccc2nc1c3ccc(C)cc3
ACDLabs 12.01CN(C)C(=O)Cc1c(nc2ccc(C)cn12)c1ccc(C)cc1
FormulaC19 H21 N3 O
NameZolpidem
ChEMBLCHEMBL911
DrugBankDB00425
ZINCZINC000000003876
PDB chain8g5h Chain C Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8g5h Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		Y58 F77 T142 E189
Binding residue
(residue number reindexed from 1)		Y34 F53 T118 E165
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8g5h, PDBe:8g5h, PDBj:8g5h
PDBsum8g5h
PubMed37730991
UniProtP22723|GBRG2_MOUSE Gamma-aminobutyric acid receptor subunit gamma-2 (Gene Name=Gabrg2)

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