Structure of PDB 8g4s Chain D Binding Site BS01

Receptor Information
>8g4s Chain D (length=209) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVRRDEENVYYSKYLNDCIMEAELHEFFSRELVDAGYASCSLCRTIDSIC
VIIQCAEPEVVMGDNHYRLHKIEYLLAGRFMCDPKNFNIWVDKIIKRGLS
AEIMVDNLRAKLEEAMPIRRAAYSIIRTAMRAGAAGCEVIVAGKLRAQRA
RANKFKEGCLISTGHPKRIFLAEATRHIKMRQGVIGVKVRIYNPNIRGAV
MPDKIEIGA
Ligand information
>8g4s Chain 2 (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcac
cccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacg
ugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggccc
gcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgag
ggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccug
cgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaa
ugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggccca
cagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaa
uuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccgua
guuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccgu
uggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagcc
ccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaaca
ggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgcc
ucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccac
cguauucccggccguaaacggugccgccccgcggccggcgcgcgcguccc
gccggccgcccagggaaaccgggaggcuccgggcucuggggggaguaugg
ccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacgug
gagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggac
gcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcggugg
ugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgaca
acgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcggg
aggacggcggggcgauagcaggucugugaugcccucagacgcccugggcc
gcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcgg
agcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagg
aaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccc
cuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgc
cccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagu
cguaacaagguauccguaggugaaccugcggauggaucccu
...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<.<<<.........>>>>>......<<........<<<..<<..
<<...<<<<<.........<<.....<<<<<<....>>>>>>......>>
.....<<....<<<...(((..<.....>..>>>...>>.......>.>>
>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>
>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<...
.......>>>>>>.<.<<....>>.>...>>>>>>.........<<<...
.<<<<...>>>>..>>>..>...>>>>>............<<<<<<....
.....>>>>>>.....<<<<<((....<<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...
<<<.......<<<.<<<<<<.<.....<<..<<.......>>........
....>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>....
......<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.
>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.
>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>
>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>
>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<
<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<.<<<<<<.
.<<<.<<<<<<......<<........>>.........<<<<<.<....<
<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<
<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....
>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>
........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...
>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>....
...>>>>>>>......<....<<.<<<<......>>>>.>>....>....
.>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.
<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.
>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g4s The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		V5 R6 R7 E10 A145 K147 Q151 R152 A153 S165 T166 G167 H168 R184 Q185 V187 K191
Binding residue
(residue number reindexed from 1)		V2 R3 R4 E7 A142 K144 Q148 R149 A150 S162 T163 G164 H165 R181 Q182 V184 K188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g4s, PDBe:8g4s, PDBj:8g4s
PDBsum8g4s
PubMed38242118
UniProtA8B8Z2

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