Structure of PDB 8fnn Chain D Binding Site BS01

Receptor Information
>8fnn Chain D (length=47) Species: 9606,11698 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKII
Ligand information
Receptor-Ligand Complex Structure
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PDB8fnn Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		W243 E246 G247 A248 V250 R263
Binding residue
(residue number reindexed from 1)		W22 E25 G26 A27 V29 R42
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:8fnn, PDBe:8fnn, PDBj:8fnn
PDBsum8fnn
PubMed37478179
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
P42166

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